Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes

dc.contributor.authorScriba, Thomas Jens
dc.contributor.authorTreurnicht, Florette K.
dc.contributor.authorZeier, Michelle D.
dc.contributor.authorEngelbrecht, Susan
dc.contributor.authorJanse van Rensburg, Estrelita
dc.date.accessioned2007-07-31T09:55:38Z
dc.date.available2007-07-31T09:55:38Z
dc.date.issued2001-05
dc.descriptionThe publisher does not allow open access to the full text of this sequence note. If you however need access to the full text, please contact the Collection Administrator, or access the item via the e-journal collection.en
dc.description.abstractTo acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.en
dc.description.sponsorshipThis work was supported by grants from the South African AIDS Vaccine Initiative and the Poliomyelitis Research Foundationen
dc.format.extent406732 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citationScriba, TJ, Treurnicht, FK, Zeier, M, Engelbrecht, S & Janse van Rensburg, E 2001,'Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes', Aids Research and Human Retroviruses, vol. 17, no. 6, pp. 775-781. [http://www.liebertonline.com/aid?]en
dc.identifier.issn0889-2229
dc.identifier.other10.1089/088922201750237059
dc.identifier.urihttp://hdl.handle.net/2263/3218
dc.language.isoenen
dc.publisherMary Ann Lieberten
dc.rightsMary Ann Liebert.en
dc.subjectHIV-1en
dc.subject.lcshHIV (Viruses) -- Genetic aspects
dc.subject.lcshHIV (Viruses) -- Research -- South Africa
dc.subject.lcshAIDS vaccines -- South Africa
dc.titleCharacterization and phylogenetic analysis of South African HIV-1 subtype C accessory genesen
dc.typeTexten

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