Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes
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Date
Authors
Scriba, Thomas Jens
Treurnicht, Florette K.
Zeier, Michelle D.
Engelbrecht, Susan
Janse van Rensburg, Estrelita
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert
Abstract
To acquire new knowledge about the genetic diversity and potential impact on vaccine strategies of HIV-1 subtype C in South Africa, we have characterized the vif, vpr, and vpu genes of 15 isolates. Phylogenetic analysis of the genomic fragment encompassing these genes revealed subtype C subclusters, suggesting close relatedness with subtype C strains from other geographic locations and excluded isolation of South African strains. The putative T155 phosphorylation site in the C terminal of Vif was absent in all subtype C sequences. Variation in the predicted amino acid sequences of the three genes further showed strong correlation with other subtype C sequences.
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Keywords
HIV-1
Sustainable Development Goals
Citation
Scriba, TJ, Treurnicht, FK, Zeier, M, Engelbrecht, S & Janse van Rensburg, E 2001,'Characterization and phylogenetic analysis of South African HIV-1 subtype C accessory genes', Aids Research and Human Retroviruses, vol. 17, no. 6, pp. 775-781. [http://www.liebertonline.com/aid?]