Genetic analysis of the complete gag and env genes of HIV type 1 subtype C primary isolates from South Africa
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Date
Authors
Engelbrecht, Susan
De Villiers, Tania
Sampson, Candice C.
Zur Megede, Jan
Barnett, Susan W.
Janse van Rensburg, Estrelita
Journal Title
Journal ISSN
Volume Title
Publisher
Mary Ann Liebert
Abstract
South Africa has one of the fastest growing HIV-1 epidemics, with an estimated 4.7 million people infected.
To better understand the genetic diversity of this epidemic and its potential impact on vaccine development, we have cloned and sequenced the complete gag and env genes of 13 primary virus isolates. Phylogenetic analysis
of our sequences and 69 complete env genes from the Los Alamos and GenBank databases revealed multiple subclusters within subtype C. The V3 loop region was relatively conserved in all our strains when compared with other subtypes, but the region immediately downstream was highly variable. No intersubtype recombinant forms were observed when comparing the gag and env sequences. Characterization of the complete
gag and env genes enabled us to select specific strains for further vaccine development.
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Keywords
HIV-1
Sustainable Development Goals
Citation
Engelbrecht, S, De Villiers, T, Sampson, CC, Zur Megede, J, Barnett, SW & Janse van Rensburg, E 2001,'Genetic analysis of the complete gag and env genes of HIV-1 subtype C primary isolates from South Africa', Aids Research and Human Retroviruses, vol. 17, no. 16, pp. 1533-1547. [http://www.liebertonline.com/aid?]