Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model
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Date
Authors
Mambwe, Dickson
Korkor, Constance M.
Mabhula, Amanda
Ngqumba, Zama
Cloete, Cleavon
Kumar, Malkeet
Barros, Paula Ladeia
Leshabane, Meta Kgaogelo
Coertzen, Dina
Taylor, Dale
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Publisher
American Chemical Society
Abstract
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Description
Keywords
Astemizole, Repositioning, Plasmodium falciparum, Plasmodium berghei, Human ether-á-go-go-related gene (hERG), Live-cell microscopy
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Citation
Mambwe, D., Korkor, C.M., Mabhula, A. et al. 2022, 'Novel 3-trifluoromethyl-1,2,4-oxadiazole analogues of astemizole with multi-stage antiplasmodium activity and in vivo efficacy in a Plasmodium berghei mouse malaria infection model', Journal of Medicinal Chemistry, vol. 65, no. 24, pp. 16695–16715, doi : 10.1021/acs.jmedchem.2c01516.