Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample
| dc.contributor.author | Janse van Rensburg, Estrelita | |
| dc.contributor.author | Engelbrecht, Susan | |
| dc.contributor.author | Van Heerden, Willem Francois Petrus | |
| dc.contributor.author | Raubenheimer, E.J. | |
| dc.contributor.author | Schoub, Barry D. | |
| dc.date.accessioned | 2007-07-25T08:25:35Z | |
| dc.date.available | 2007-07-25T08:25:35Z | |
| dc.date.issued | 1995-05 | |
| dc.description | This article was co-written by Prof Janse van Rensburg before she joined the University of Pretoria. | en |
| dc.description.abstract | The purpose of this study was to determine the presence of Epstein-Barr virus (EBV) DNA in oral squamous cell carcinoma (OSCC) patients from a black African population. Formalin fixed paraffin embedded blocks of OSCC of two randomly selected groups were investigated. Group 1 consisting of 57 blocks containing OSCC with a fragment of normal appearing adjacent/overlying epithelium. Group 2 consisted of 48 blocks containing only OSCC tissue without any normal appearing epithelium. The control group consisted of 38 non-malignant, non-viral associated lesions. A standard polymerase chain reaction (PCR) was used to amplify the Bam HI W-fragment using a nested primer set. EBV DNA was demonstrated in 14/57 (25%) blocks from Group 1, in 13/48 (27%) blocks from Group 2 and in 16/38 (42%) blocks from the control group. No evidence for a direct role of EBV in the process of malignant transformation of intraoral epithelial cells was found in this study. | en |
| dc.format.extent | 8503 bytes | |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | Janse van Rensburg, E, Engelbrecht, S, Van Heerden, WFP, Raubenheimer, E & Schoub BD 1995, 'Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample', In Vivo, vol. 9, no. 3, pp. 199-202. [http://www.iiar-anticancer.org/invivo/invivo_index.htm] | en |
| dc.identifier.issn | 0258-851X | |
| dc.identifier.uri | http://hdl.handle.net/2263/3136 | |
| dc.language.iso | en | en |
| dc.publisher | International Institute of Anticancer Research | en |
| dc.rights | International Institute of Anticancer Research The publisher prohibits open access to the full text of this article. | en |
| dc.subject.lcsh | Squamous cell carcinoma -- Blacks -- Africa | |
| dc.subject.lcsh | Epstein-Barr virus -- Research -- Blacks -- Africa | |
| dc.title | Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample | en |
| dc.type | Article | en |