Title page for ETD etd-12212010-181452

Document Type Master's Dissertation
Author Suarez, Martin Alejandro
URN etd-12212010-181452
Document Title Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs
Degree MSc
Department Companion Animal Clinical Studies
Advisor Name Title
Mr F G Stegmann Co-Supervisor
Dr T B Dzikiti Supervisor
  • alfaxalone
  • propofol
  • anaesthesia
  • ovariohysterectomy in dogs
Date 2010-11-26
Availability unrestricted
Objective To compare the anaesthetic and cardiopulmonary effects of alfaxalone in comparison to propofol when used for total intravenous anaesthesia (TIVA) during ovariohysterectomy in dogs.

Animals Fourteen healthy female crossbred dogs between 6 months and 5 years, with body weight between 16 - 42 kg.

Methods All dogs were premedicated with acepromazine 0.01 mg/kg and morphine 0.4 mg/kg subcutaneously. Anaesthesia was induced and maintained with either Group 1- propofol (6 mg/kg followed by 0.3-0.5 mg/kg/min intravenously) or Group 2 alfaxalone (2 mg/kg followed 0.10-0.12 mg/kg/min intravenously). Quality of induction and recovery were determined. Dogs were spontaneously breathing 100 % oxygen. Respiratory and cardiovascular parameters were measured: Respiratory rate (RR), end tidal CO2 (ETCO2), tidal volume (TV). Heart rate (HR), systolic (SAP), diastolic (DAP), and mean arterial blood pressure (MAP). Arterial blood samples were collected during and after the surgery to determinate arterial PH, PaCO2, PaO2.

Results Smooth and rapid induction followed by satisfactory maintenance and good recovery quality was observed with both anaesthetic agents. Cardiopulmonary effects were similar for both groups with notable respiratory depression and fair hemodynamic parameters.

Conclusions and Clinical Relevance The administration of alfaxalone used as TIVA in premedicated dogs produced satisfactory anaesthesia with the same quality as that produced by propofol during ovariohysterectomy. Hypoventilation was the most prominent adverse effect from both anaesthetic agents suggesting a need for ventilatory support during prolonged TIVA periods with either anaesthetic agent.

2010 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria

Please cite as follows:

Suarez, MA 2010, Comparison of alfaxalone and propofol administered for total intravenous anaesthesia during ovariohysterectomy in dogs, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-12212010-181452 / >


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