Title page for ETD etd-11212005-165303


Document Type Master's Dissertation
Author Tsanwani, Mutshutshu
URN etd-11212005-165303
Document Title Application of sequential injection systems in the assay of pharmaceutical products
Degree MSc (Chemistry)
Department Chemistry
Supervisor
Advisor Name Title
Prof J F Van Staden Committee Chair
Keywords
  • sequential injection analysis
  • drugs analysis
  • paracetamol
Date 2001-04-01
Availability unrestricted
Abstract
The concept of sequential injection analysis (SIA), introduced as a simple and convenient principle, has established itself as a well defined analytical technique suitable for routine laboratory analysis. This technique is fully computerized and reliable with a reasonable sample frequency, low sample and reagent consumption and low frequency of maintenance.

In pharmaceutical based analysis SIA can be used at each step through the entire production process, from raw material to the final consumer product. With its substantial advantages, an SIA system can replace sophisticated instrumentation facilities, which are unlikely to be used for manufacturing environments.

The aim of this study was to investigate the application of the sequential injection analysis technique in the determination of selected substances of biological importance from the pharmaceutical industry (zinc, paracetamol and boron). It is important to control the level of zinc and boron in human, animals and plants. Overdose of paracetamol is a problem in our body. That is why the uniformity tests of paracetamol must be very accurate and precise. The aim was successfully achieved. The results obtained for all substances proved the high reliability of the SIA technique.

2001, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.

Please cite as follows:

Tsanwani, M 2001, Application of sequential injection systems in the assay of pharmaceutical products, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-11212005-165303/ >

H724/ag

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