Title page for ETD etd-11172006-092708


Document Type Master's Dissertation
Author Pienaar, Danie
URN etd-11172006-092708
Document Title Synthetic applications of bicyclic phosphoric triamides
Degree MSc (Chemistry)
Department Chemistry
Supervisor
Advisor Name Title
Prof T A Modro Committee Chair
Keywords
  • chemistry organic
  • amidines
Date 2000-04-01
Availability unrestricted
Abstract
Bis(2-arylaminoethyl)amines cannot be efficiently prepared by the obvious route from bis(2-chloroethyl)amine and anilines, as intramolecular cyclisation to piperazine is favoured over a second substitution to form the open triamine. A series of bis(2¬arylaminoethyl)amines was successfully prepared via a new and general route, the facile cleavage under acidic conditions of the corresponding bicyclic phosphoric triamides. In some cases, the resultant amines were functionalised further, ego yielding the trihydrochloride salts and the tri-N-acetylated derivatives. The base hydrolysis of the bicyclic phosphoric triamides in turn, may lead to the formation of interesting amino acids or zwitterions, as demonstrated for one of the derivatives.

© 2000, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.

Please cite as follows:

Pienaar, D 2000, Synthetic applications of bicyclic phosphoric triamides, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-11172006-092708/ >

H683/ag

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