Document Type Master's Dissertation Author Pienaar, Danie URN etd-11172006-092708 Document Title Synthetic applications of bicyclic phosphoric triamides Degree MSc (Chemistry) Department Chemistry Supervisor
Advisor Name Title Prof T A Modro Committee Chair Keywords
- chemistry organic
Date 2000-04-01 Availability unrestricted AbstractBis(2-arylaminoethyl)amines cannot be efficiently prepared by the obvious route from bis(2-chloroethyl)amine and anilines, as intramolecular cyclisation to piperazine is favoured over a second substitution to form the open triamine. A series of bis(2¬arylaminoethyl)amines was successfully prepared via a new and general route, the facile cleavage under acidic conditions of the corresponding bicyclic phosphoric triamides. In some cases, the resultant amines were functionalised further, ego yielding the trihydrochloride salts and the tri-N-acetylated derivatives. The base hydrolysis of the bicyclic phosphoric triamides in turn, may lead to the formation of interesting amino acids or zwitterions, as demonstrated for one of the derivatives.
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Please cite as follows:
Pienaar, D 2000, Synthetic applications of bicyclic phosphoric triamides, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-11172006-092708/ >
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