Title page for ETD etd-08102010-182351


Document Type Master's Dissertation
Author Gatley, Joan Marguerite
Email wandsbeck@mweb.co.za
URN etd-08102010-182351
Document Title The prevalence of Leptospira serovars causing infection in dogs in South Africa
Degree MSc
Department Veterinary Tropical Diseases
Supervisor
Advisor Name Title
Dr J Picard Co-Supervisor
Prof M Van Vuuren Supervisor
Keywords
  • infection in dogs
  • L. Pyrogenes
  • Leptospira serovars
  • L. Canicola
  • South Africa
Date 2010-04-16
Availability unrestricted
Abstract

Leptospirosis is a disease of global importance with a changing epidemiology in both humans and animals. It is also a significant zoonosis particularly in the developing world. To date there is limited knowledge of the incidence of leptospirosis in dogs in South Africa. This study was undertaken on a subset of dogs in South Africa to determine the presence of leptospiral antibodies to serovars known to infect dogs. Serum samples from both stray and owned dogs from various parts of South Africa were collected and tested against fifteen serovars of Leptospira. Five hundred and thirty samples were tested and twenty-five tested positive to seven different serovars. Nine of the 25 samples tested positive to more than one serovar. The two serovars that were most frequently represented were L. Canicola, which reacted to seventeen sera, and L. Pyrogenes, which reacted to nine sera in all. Currently the only vaccines available in South Africa in different combinations contain either L. Canicola, L. Icterohaemorrhagiae, L. Pomona or L. Grippotyphosa. The results show that the use of vaccines containing L. Canicola is still justifiable in certain regions of the country. However, the presence of antibodies to L. Pyrogenes in several dogs indicates that there is a need to investigate for the presence of antibodies in a larger group of dogs. This would allow vaccine manufacturers to tailor the Leptospira antigens present in vaccines to include those that are prevalent in a particular region or country.

Copyright 2009, University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.

Please cite as follows:

Gatley, JM 2009, The prevalence of Leptospira serovars causing infection in dogs in South Africa, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-08102010-182351/ >

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