Title page for ETD etd-07112011-170301


Document Type Master's Dissertation
Author Naidoo, Kersch
URN etd-07112011-170301
Document Title A novel preparation method for porous hemi-spherical bio-polymeric microparticles
Degree MEng
Department Chemical Engineering
Supervisor
Advisor Name Title
Dr H Rolfes Supervisor
Keywords
  • microparticles
  • porogen
  • oil-in-water
  • cavity
  • microporous
  • tissue engineering
  • drug delivery
  • hemi-shells
  • polycaprolactone
  • emulsion
Date 2011-04-15
Availability unrestricted
Abstract
A modified oil-in-water emulsion process was developed to produce novel microporous hemi-spherical polycaprolactone (PCL) microparticles called “hemi-shells”. Through the addition of a porogen such as sodium bicarbonate into the PCL-dichloromethane oil phase and emulsification in an acidic polyvinyl alcohol aqueous phase, microporous hemi-shells formed as dichloromethane evaporated. Carbon dioxide gas evolution from the porogen reaction with the acidic aqueous phase created particles with an externally microporous shell and a large internal cavity. The hemi-shells were characterized by various methods, including scanning electron microscopy and optical microscopy which were specifically used to quantify the hemi-shell yield. The final number-average particle yield of the optimised manufacturing method for particle manufacture in the 50-200 micron size range was 84%. The number-average hemi-shell yield in the same size range was 41%. These novel microparticles have potential applications in tissue engineering and drug delivery

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Please cite as follows:

Naidoo, K 2010, A novel preparation method for porous hemi-spherical bio-polymeric microparticles, MEng dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-07112011-170301/ >

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