Title page for ETD etd-06152011-145610

Document Type Master's Dissertation
Author Weyer, Camilla Theresa
URN etd-06152011-145610
Document Title African horse sickness virus dynamics and host responses in naturally infected horses
Degree MSc
Department Veterinary Tropical Diseases
Advisor Name Title
Prof A J Guthrie Co-Supervisor
Dr M Quan Supervisor
  • Orbivirus
  • AHS
  • African horse sickness
  • Culicoides
  • Reoviridae
Date 2011-04-08
Availability unrestricted
African horse sickness (AHS) is a life threatening disease of equids caused by African horse sickness virus (AHSV), a member of the genus Orbivirus in the family Reoviridae. The virus is transmitted to horses by midges (Culicoides spp.) and the disease is most prevalent during the time of year, and in areas where the Culicoides spp. are most abundant, namely in late summer in the summer rainfall areas of the country. Whilst the clinical signs and presentation of the disease were well documented by Sir Arnold Theiler (1921), very little is known or documented about AHSV dynamics or the clinical pathological and serological responses of horses to natural infection with AHSV.

This dissertation describes the history and current knowledge on AHS, and the methods and results of a prospective study on natural AHSV infection of horses, undertaken between 2009 and 2010 by the Equine Research Centre (ERC) at the University of Pretoria, Faculty of Veterinary Science, Onderstepoort. This study is the first documented study of its nature and included animals of various ages and therefore variable vaccination status. The objectives of the study were to describe the viral dynamics of AHSV infection in horses, to gain a better understanding of the clinical pathological and serological responses to natural AHS infection and to demonstrate early detection of AHS infection in horses under field conditions.

2010 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.

Please cite as follows:

Weyer, CT 2010, African horse sickness virus dynamics and host responses in naturally infected horses, MSc dissertation, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-06152011-145610/>


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