Title page for ETD etd-04282012-152258

Document Type Doctoral Thesis
Author Van Zyl, Daniel Gerhardus
URN etd-04282012-152258
Document Title Inpatient diabetes care : evaluation and intervention
Degree PhD
Department Internal Medicine
Advisor Name Title
Prof P Rheeder Supervisor
  • inpatient diabetes management protocol
  • audit
  • diabetic ketoacidosis
  • ringerís lactate solution
  • glycaemic control
  • 0.9% sodium chloride solution
  • inpatient
  • diabetes
  • attitudes
  • knowledge
Date 2012-04-13
Availability unrestricted
The management of patients hospitalised with diabetes mellitus is neglected in South Africa. The research on which this thesis is based assessed factors contributing to glycaemic control as well as evaluated an intervention aimed at improving of such control in diabetic inpatients.

A survey of doctors and nurses measuring their perceptions, knowledge and attitudes regarding care of diabetic inpatients was done. This indicated a need for special training in inpatient diabetes care, where 90.5% of respondents realised that diabetes is a serious condition and 92.2% valued the importance of tight glycaemic control. Despite these perceptions, the knowledge of doctors and nurses caring for diabetic inpatients was suboptimal.

A before and after study regarding an intervention to improve glycaemic control of diabetic inpatients consisted of a training programme and the introduction of an inpatient management protocol. The mean blood glucose on day one of admission after the intervention was significantly higher than before the intervention (p < 0.001). A significant improvement in mean blood glucose from day 1 to day 7 of hospitalisation was seen after the intervention (p < 0.001), which was not significant before (p = 0.33). The proportion of patients achieving glycaemic control did not significantly differ before and after the intervention (43.0% versus 43.7%, p = 0.97).

A double blind randomised controlled trial to assess superiority of Ringerís lactate solution compared to 0.9% Sodium chloride solution in the normalisation of pH in patients with diabetic ketoacidosis was done. The outcome of this study indicated that the time to normalisation of venous pH (pH > 7.32) (HR: 1.863, CI: 0.937 to 3.705, p = 0.758) was not significantly different between the two resuscitation fluid groups The time to reach a blood glucose of 14 mmol/L was significantly longer in the Ringerís lactate group (p = 0.044) and patients needed significantly more insulin (p = 0.02). The overall conclusion of this study is that there is no significant benefit in using Ringerís lactate solution as initial resuscitation fluid compared to the currently advised 0.9% Sodium chloride solution.

© 2012 University of Pretoria. All rights reserved. The copyright in this work vests in the University of Pretoria. No part of this work may be reproduced or transmitted in any form or by any means, without the prior written permission of the University of Pretoria.

Please cite as follows:

Van Zyl, DG 2012, Inpatient diabetes care : evaluation and intervention, PhD thesis, University of Pretoria, Pretoria, viewed yymmdd < http://upetd.up.ac.za/thesis/available/etd-04282012-152258/ >


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  00front.pdf 171.57 Kb 00:00:47 00:00:24 00:00:21 00:00:10 < 00:00:01
  01chapter1.pdf 216.00 Kb 00:00:59 00:00:30 00:00:26 00:00:13 00:00:01
  02chapter2.pdf 184.53 Kb 00:00:51 00:00:26 00:00:23 00:00:11 < 00:00:01
  03chapter3.pdf 194.17 Kb 00:00:53 00:00:27 00:00:24 00:00:12 00:00:01
  04chapter4.pdf 409.66 Kb 00:01:53 00:00:58 00:00:51 00:00:25 00:00:02
  05chapter5.pdf 211.13 Kb 00:00:58 00:00:30 00:00:26 00:00:13 00:00:01
  06chapter6.pdf 550.37 Kb 00:02:32 00:01:18 00:01:08 00:00:34 00:00:02
  07conclusion.pdf 135.74 Kb 00:00:37 00:00:19 00:00:16 00:00:08 < 00:00:01
  08appendices.pdf 276.63 Kb 00:01:16 00:00:39 00:00:34 00:00:17 00:00:01

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