Synthesis and bioactivity studies of benzimidazole–chalcone hybrids

Abstract

Chalcones featuring α,β–unsaturated carbonyl group are associated with an extensive range of pharmacological properties. The synthesized derivatives of benzimidazole–chalcone are prominent classes of bioactive compounds that have demonstrated significant applications. Recently, there has been an encouraged demand for synthesizing aromatic N–heterocyclic α,β–unsaturated hybrids that comprise benzimidazole–chalcones, which could be evaluated for activities against several diseases. The current review presents the synthetic approaches of the recently prepared benzimidazole–chalcone compounds and their biological applications. The biological activity studies include cytotoxicity against several cancer cells, antibacterial, antifungal, antileishmanial, antimalarial, antiviral and antidiabetic activities. The in silico studies of hybridized benzimidazole–chalcones are also discussed. Therefore, the review shows the significance of benzimidazole–chalcone derivatives and their potential as effective bioactive agents.